Risk Assessment Methodology: Maximum Tolerated Dose and Two-Stage Carcinogenesis Models
نویسندگان
چکیده
منابع مشابه
Regulatory cancer risk assessment based on a quick estimate of a benchmark dose derived from the maximum tolerated dose.
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Mechanistic multi-stage models are used to analyze lung-cancer mortality after Plutonium exposure in the Mayak-workers cohort, with follow-up until 2008. Besides the established two-stage model with clonal expansion, models with three mutation stages as well as a model with two distinct pathways to cancer are studied. The results suggest that three-stage models offer an improved description of ...
متن کاملCorrection: Beyond Two-Stage Models for Lung Carcinogenesis in the Mayak Workers: Implications for Plutonium Risk
to correct formatting errors in the figures and tables. The publisher apologizes for the errors. Please download this article again to view the correct version. The originally published, uncorrected article and the republished, corrected article are provided here for reference. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricte...
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Existing security risk assessment methodologies have three major flaws: they rely on the assessor to formulate the chain of events that describe each of its threat scenarios, their models cause a combinatorial explosion of calculations due to analysis of the effectiveness of each countermeasure against each threat/vulnerability pair, and they do not spotlight the specific area of improvement ne...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1994
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339402200213